Abstract
Hypertrophic cardiomyopathy (HCM) is a relative common [about 1:500 in the general adult population], genetic cardiac disorder in which a portion of the myocardium becomes hypertrophied. In up to 70% of HCM patients, dynamic left ventricular outflow tract (LVOT) obstruction is present either at rest or is inducible with stress. Obstructive HCM is associated with worsened symptom severity, disease progression and HCM-related death (relative risk vs non-obstructive HCM, 2.0). The mechanism of dynamic obstruction in HCM is not understood. For the patients who do not respond to medication, surgical septal myomectomy (SSM) procedure may relieve the outflow obstruction. However, SSM is not always successful. Failure to alleviate obstruction frequently results from inadequate excision. Conversely, resection may be complicated by ventricular septal defect or complete heart block. Cardiac magnetic resonance (MR) & Computational fluid dynamics (CFD) derived heart blood flow is able to provide detailed hemodynamic information like 3-dimensional velocity profile and pressure gradient and vorticity formation. By comparing the vortex formation in HCM versus normal heart, we can hopefully begin to understand the propensity to initiate, develop and maintain outflow obstruction. Further, the recognition of the flow pattern may lead to modification of surgical septal myectomy technique in HCM.

Biography
Dr. Leong Chong is the lead researcher of National Heart Center in Singapore, the director of the Engineering Department of the Research Institute of NHCS, Associate Professor of Duke/NUS Graduate Medical School in Singapore, Guest Professor of School of Medicine Wuhan University of Science and Technology, Guest Professor of Wuhan Hospital on Heart Disease of Asia. Dr. Chong graduated with dual Bachelor Degrees from Huazhong University of Science and Technology in the year of 1999, got PhD from NTU in the year of 2005, and visited the School of Medicine, University of Bologna, Italy in the year of 2007.
His major study field includes cardiovascular imaging, cardiovascular engineering, cardiovascular mechanics, models and simulation, and noninvasive cardiac stress diagnosis and evaluation. Chong successively got the Best Researcher Award of SHA(2011 and 2012), the Best Researcher Award of APHA(2012) and the Sejong Medical Award of APCCS(2012). Hitherto, Dr. Chong has led and co-led more than ten national and international research funds, and applied for 7 patents in the US and in Singapore. Chong has published over 60 papers on the peer reviewed SCI journals, including Int J Cardiol, Am J Cardiol, Am J Physiol.

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