生物医学工程系学术报告9.7(报告人:Barbara P. Chan Ph.D)
发布时间: 2010-08-31 10:40:00
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北京大学工学院 生物医学工程系学术报告 |
报告一题目：Mesenchymal stem cell collagen microspheres for cartilage tissue engineering
报告二题目：Effects of collagen matrix on fates of mouse embryonic stem cells during chondrogenic differentiation
报告人 Barbara P. Chan Ph.D
Associate Professor, Medical Engineering
Department of Mechanical Engineering
The University of Hong Kong
报告一内容摘要：
Collagen microencapsulation is an emerging platform technology for tissue engineering. Many cells including mesenchymal stem cells (MSCs) can be entrapped in reconstituted collagen fibrous meshwork, resulting in formation of cell collagen microspheres. Applications of this technology in cartilage tissue engineering will be discussed. Specifically, bone marrow derived MSCs were microencapsulated in collagen microspheres and differentiated towards chondrogenic lineages. The differentiating MSCs remodeled the collagen microspheres into cartilage-like tissue micromasses. Finally, the efficacy of using these microspheres for cartilage repair in a rabbit model will also be discussed in this talk.
报告二内容摘要：
Embryonic stem (ES) cells hold great potential in regenerative medicine although controlling their differentiation into homogeneous lineages is challenging. In this study, we aim to investigate the effects of reconstituted 3D collagen matrix on fates of mouse ES (mES) cells before and after induction for chondrogenic differentiation at different time points. Collagen microspheres provided a suitable microenvironment supporting mES cell growth and maintaining their undifferentiated status for certain period of time. At later time points, the proportion of undifferentiated mES cells gradually decreased, accompanied by increasing proportions of mesenchymal progenitor cells. This suggests the inductive role of collagen matrix in differentiating mES cells towards mesenchymal lineages. Moreover, both the initial collagen concentration and the time to induce differentiation significantly affected the fates of mES cells.
主持人：葛子钢 特聘研究员
时间：9月7日（周二）下午1:30
地点：廖凯原楼2-102会议室
欢迎广大老师和学生参加！