力学系和生医系联合学术报告12.24（报告人：Ke Bai）
发布时间: 2010-12-23 04:51:00
SEMINAR SERIES
北京大学工学院 
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力学与空天技术系
湍流与复杂系统国家重点实验室
题目：The Endothelial Glycocalyx: A Crucial Structure In The Vascular System
Ke Bai
Department of Engineering, Queen Mary, University of London
Abstract
Vascular and related diseases account for >50% of all unnatural deaths in western countries. In the circulation system, endothelial cells (ECs) spread the entire luminal surface of blood vessels. The surface of ECs is covered by a hair-liked thin layer (a few hundred nm thick), which is negatively charged, known as the glycocalyx. As the outmost interface between the blood vessel and blood, the endothelial glycocalyx mediates the interaction between the blood and the endothelium, and plays a crucial role as an endothelial mechanotransducer. Hence, it involves in the initiation and progress of vascular diseases, such as atherosclerosis. In the present study, we compared the endothelial glycocalyx in vivo and in vitro. A time dependent trend has been discovered as a criterion of healthy glycocalyx in vitro. The mechanical properties of glycocalyx was also been demonstrated as one of the indicators.
About the Speaker
Graduated from the combined B.Sc and M.Sc program in the School of Pharmaceutical Science of Peking University in 2007. Then worked as a research assistant in School of Biological Science and medical Engineering, Beijing University of Aeronautics and Astronautics from 2007 to 2008. Have been doing Ph.D in biomedical engineering in the Department of Engineering, Queen Mary, University of London since 2008. The following scholarships have been awarded: Overseas Research Student Award and College DTA Studentship, School of Engineering and Material Science.
Areas of research: drug delivery through blood brain barrier, the relationship between the function and properties of tooth, the differentiation of mesenchymal stem cell, endothelial glycocalyx and mechanotransductions.
These researches have been published on various journals, including: Journal of Biomechanics, Materials Science and Engineering, Chinese Science Bulletin, etc. and a Chinese patent in addition.
主持人：陈十一 院长
时 间：12月24日（周五）上午9:00~11:00
地 点：力学楼434会议室
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