北京大学工学院生物医学工程系9.16(报告人 Dr. Jin-Biao Ma)
发布时间: 2009-09-14 09:27:00
北京大学工学院
生物医学工程系
Recognition and modification of small silencing RNAs: structures and mechanisms
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报告人 Dr. Jin-Biao Ma
Assistant Professor, Tenure-track
Department of Biochemistry and Molecular Genetics
University of Alabama at Birmingham
720 20th St. S., Birmingham, AL 35294
Phone: (205) 934-4713
Email: jma（at）biochemistry.uab.edu
报告内容摘要：
RNA silencing is a conserved regulatory mechanism in fungi, plants and animals to regulate gene expression and defense against viruses and transgenes. Small silencing RNAs of ~20 to 30 nucleotides (nt) and their associated effector proteins, members of the Argonaute family proteins, are the central components in RNA silencing. Although a rapidly growing number of small silencing RNAs have emerged, most of them belong to three classes based on their distinct structures and biogenesis: small interfering RNAs (siRNAs), microRNAs (miRNAs) and Piwi-interacting RNAs (piRNAs). A subset of small RNAs, such as miRNAs and siRNAs in plants, piRNAs in animals and siRNAs in Drosophila, require an additional crucial step for their maturation, 2’-O-methylation on the 3’ terminal nucleotide. A conserved S-adenosyl-L-methionine (AdoMet)-dependent RNA methyltransferase, HUA ENHANCER 1 (HEN1), and its homologs are responsible for this specific modification. Based on structural and biochemical studies in my lab, I will present the molecular basis for the recognition and molecular mechanism for the 3’-end methylation of small silencing RNAs.
主持人：席建忠
时 间：9月16日（周三）上午10:00
地 点：北京大学廖凯原2-102会议室
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