北京大学工学院先进材料与纳米技术系学术报告（报告人 Shouheng Sun）
发布时间: 2009-07-08 10:18:00
北京大学工学院
先进材料与纳米技术系学术报告
题目：Porous Hollow Fe3O4 Nanoparticles for Targeted Delivery and Controlled Release of Cisplatin
报告人 Shouheng Sun 教授
布朗大学化学系
主持人：侯仰龙 特聘研究员
时 间：7月10日（周五）上午9:30
地 点：化学楼A815（会议室）
报告内容摘要：
I will summarize a new approach to cisplatin storage and release using porous hollow nanoparticles (PHNPs) of Fe3O4. We prepared the PHNPs by controlled oxidation of Fe NPs at 250 °C followed by acid etching. The opening pores (2-4 nm) facilitated the cisplatin diffusion into the cavity of the hollow structure. The porous shell was stable in neutral or basic physiological conditions, and cisplatin escape from the cavity through the same pores was a diffusion-controlled slow process with t1/2 = 16 h. However, in low pH (<6) conditions, the pores were subject to acidic etching, resulting in wider pore gaps and faster release of cisplatin with t1/2 < 4 h. Once coupled with Herceptin to the surface, the cisplatin-loaded hollow NPs could target to breast cancer SK-BR-3 cells with IC50 reaching 2.9 ?M, much lower than 6.8 ?M needed for free cisplatin. Our model experiments indicate that the low pH-responsive PHNPs of Fe3O4 can be exploited as a cisplatin delivery vehicle for target-specific therapeutic applications.
报告人简介：
Professor Sun received his Ph.D. degree in Chemistry from Brown University in 1996. He was a postdoctoral fellow from 1996-1998 and a research staff member from 1998-2004 at the IBM T. J. Watson Research Center. He joined the Chemistry Department of Brown University as a tenured Associate Professor in 2005 and was promoted to full Professor in 2007. He has been the Associate Director of Brown's Institute for Molecular and Nanoscale Innovation since 2008.
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联系人：侯仰龙 hou（at）pku.edu.cn 010-8252-9028