报告1  题目：Ensemble Discovery 

报告人  Xiaoyu Li 
161 Highland Ave.Arlington, MA 02467Phone: (617)308-2361, Fax: (781)488-3010Email: xiaoyuli（at）hotmail.com; xiaoyul（at）broad.mit.edu 

报告内容摘要： 
1) Target identification: the missing link between chemical genetics and drug discovery; 
2)  Applying Nature’s strategy in discovery science: DNA programming and engineering. 

报告人简介： 
The Broad Institute of MIT and Harvard, Cambridge, MAOctober, 2007 – present Chemical Biology Platform (Initiative for Chemical Genetics project team)Research Scientist II；Ensemble Discovery Corporation, Cambridge, MA October, 2005 – September, 2007 Principal Scientist October, 2004 – October, 2005 Senior Scientist；Harvard University, Cambridge, MA October, 2002 – September, 2004 Postdoctoral Research Fellow。 
时  间：2009年4月16日（周四）下午3：10-4：10 

报告2  题目：Structural Bases of type 2B and platelet-type von Willebrand disease 

报告人  Jizhong Lou, Ph. D 
Parker H. Petit Institute for Bioengineering and Bioscience Georgia Institute of Technology 
315 Ferst Drive, Atlanta, GA 30332-0363，Tel: 404-385-7454 (o); 404-723-6760 (c) 

报告内容摘要： 
Interaction of glycoprotein Iba(GPIba) with von Willebrand factor (VWF) initiates platelet adhesion to injured vascular wall to stop bleeding. Arterial blood flow enhances binding of GPIba to VWF. Mutations in the VWF A1 domain that cause type 2B von Willebrand disease (VWD) reduce the flow requirement for adhesion. Single molecule experiments show that increasing force on GPIba/VWF bonds first prolonged (catch) and then shortened (slip) lifetimes. We demonstrate that the β-hairpin is unstable without contacting VWF, in that it switches to a loop in free molecular dynamics simulations. Simulations with a novel flow molecular dynamics algorithm show that the loop conformation is unstable in the presence of flow, as it switches to  β-hairpin even without contacting VWF. Compared with the wild-type, it is easier for the M239V mutant but harder for the A238V mutant to switch to β-hairpin in the presence of flow.  

报告人简介： 
Research Scientist II, 2005 – present, Parker H. Petit Institute for Bioengineering andBioscience, Georgia Institute of Technology, Atlanta, Georgia；Postdoctoral Fellow, 2001 – 2005, Parker H. Petit Institute for Bioengineering andBioscience, Georgia Institute of Technology, Atlanta, Georgia；Postdoctoral Fellow, 2000 – 2001, Department of Physics, University of Nevada LasVegas, Las Vegas, Nevada 

时  间：2009年4月16日（周四）下午4：10-5：10 

主持人：谢天宇教授 
地  点：北京大学廖凯原楼2-102（会议室） 
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